Experts have proved for the first time that dogs trained to respond to their owner’s low blood sugar levels can save them from a potentially fatal – hypoglycaemic attack, the Daily Express reported. The animals use their acute sense of smell to detect changes in the chemical comp-osition of their owner’s sweat or breath. They can be taught to raise the alarm by barking, pawing or even fetching a blood testing kit. All people with Type 1 diabetes and those with Type 2 diabetes who are on glucose lowering medication, including insulin, need to regularly check their blood glucose. If they take too much insulin it can result in hypoglycaemia – or a hypo – caused by abnormally low levels of sugar in the blood. Symptoms include hunger , trembling or shakiness, and sweating. In more serious cases it can affect concentration or cause slurred speech.
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4 Factors Predict Diabetes Remission After Surgery: Study
The authors of an accompanying commentary agreed. “The DiaRem score could help with selection of appropriate treatment and management of expectations held by both the patient and the multidisciplinary team involved in the patient’s care,” wrote Dimitri Pournaras and Carel le Roux, from Imperial College London, in England. “Additionally, it could scientifically improve the comparison of different surgical procedures by allowing appropriate stratification of probability of remission,” Pournaras and le Roux said. “However, further prospective studies are needed to validate these potential uses,” they said.
For the original version including any supplementary images or video, visit http://diabetes.webmd.com/news/20130913/4-factors-predict-diabetes-remission-after-surgery-study
Odd Move By Sanofi On Diabetes Drug Application
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Approved cancer drug potentially could help treat diabetes, researchers find
Treatment of normal and diabetic laboratory mice with a variety of VEGF inhibitors, including aflibercept, causes regression of blood vessels and increases the number of hypoxic cells in the liver. As a result, HIF-2alpha levels increase, IRS2 expression rises and the animals become better able to tolerate increases in blood-glucose levels. The researchers found that deletion of HIF-2alpha blocked the effect of the VEGF inhibitors, while liver-specific induction of HIF-2alpha expression also significantly improved the animals glucose tolerance. Much work remains to translate these mouse studies to human patients, but it will be interesting to explore VEGF inhibitors or drugs that can stabilize HIF-2alpha, such as prolyl hydroxylase inhibitors, for diabetes treatment, possibly in combination with pre-existing therapies to minimize toxicities, Kuo said. Taniguchi, in Giaccias lab, focused on the biology of HIF-2alpha.
For the original version including any supplementary images or video, visit http://med.stanford.edu/ism/2013/september/diabetes.html